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This volume details up-to-date information and attempts to take the
reader into the exciting realm of TGF- from the basic principles to
the practical applications. Chapters provide basic introduction of
TGF- signaling from the cell surface to the nucleus, methods and
techniques for the investigation of TGF- signaling mechanism
including receptors, Smads, intracellular kinases, microRNA,
epigenetic regulation, post-translational regulations, non-Smad
pathway; the physiological implications including those in cell
cycle arrest, epithelial-mesenchymal transition, endothelial cells,
adipogenesis, Th differentiation, stem cell, bone remodeling,
ovary, zebrofish development, and frog animal capping; and the
methodologies including metastasis imaging, 3D morphogenesis,
membrane receptor quantification, conditional knockout, bone
remodeling, kinase and phosphatase assays, BiFC interaction assays,
and genome-wide siRNA screen. Written in the highly successful
Methods in Molecular Biology series format, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols, and key tips on troubleshooting and avoiding
known pitfalls. Authoritative and practical, TGF-Beta Signaling:
Methods and Protocols aims to ensure successful results in the
further study of this vital field.
More than 40 articles provide an extensive coverage of clinical and
basic science advances over the last three years of research on
subarachnoid hemorrhage-induced brain injuries. Early brain injury,
the new frontier of subarachnoid research, which may be a key
contributor to the high mortality and morbidity, promotes
collaborative efforts from neurosurgery, neurology, neuro-ICU into
other interrelated fields and basic neurosciences. For the first
time, subarachnoid hermorrhage research is almost equally divided
by early brain injury and cerebral vasospasm, mechanistic
investigations and therapeutic approaches, demonstrating a
translational feature of the future direction.
More than 40 articles provide an extensive coverage of clinical and
basic science advances over the last three years of research on
subarachnoid hemorrhage-induced brain injuries. Early brain injury,
the new frontier of subarachnoid hemorrhage research, which may be
a key contributor to the high mortality and morbidity, promotes
collaborative efforts from neurosurgery, neurology, neuro-ICU into
other interrelated fields and basic neurosciences. For the first
time, subarachnoid hemorrhage research is almost equally divided by
early brain injury and cerebral vasospasm, mechanistic
investigations and therapeutic approaches, demonstrating a
translational feature of the future direction.
In this book, leading world authorities on brain edema and
neurological disorders/injuries and experts in preconditioning join
forces to discuss the latest progress in basic sciences,
translational research, and clinical management strategies relating
to these conditions. The range of topics covered is wide, including
microglia, energy metabolism, trace metals and ion channels,
vascular biology, cellular treatment, hemorrhagic stroke, novel
technological advances, anesthesia and medical gases, pediatric
brain edema, neuroimaging, behavioral assessment, clinical trials,
peripheral to central signaling pathways, preconditioning
translation, and animal models for preconditioning and brain edema
research. The book comprises presentations from Brain Edema 2014,
the joint meeting of the 16th International Conference on Brain
Edema and Cellular Injury and the 3rd Symposium on Preconditioning
for Neurological Disorders, held in Los Angeles on September 27-30,
2014.
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